Tirzepatide

Tirzepatide activates two receptors: GIP and GLP-1. GLP-1 helps reduce appetite, increase fullness and improve glucose-dependent insulin control. GIP adds another nutrient-related signal that works alongside it.

AOD-9604

Growth hormone does lots of things. AOD-9604 was the attempt to nick just the bit people hoped would help with fat loss and leave the growth bit behind.

Cagrilintide

Cagrilintide works on a different appetite system from the famous GLP-1 drugs. It is a long-acting analogue of amylin, a hormone normally released alongside insulin after you eat.

Eloralintide

Eloralintide, also known as LY3841136, is an investigational amylin-receptor agonist being studied for obesity. Amylin is one of the body’s natural ‘we have eaten, thank you’ signals.

Mazdutide

Mazdutide is a dual agonist: it activates both GLP-1 and glucagon receptors. GLP-1 helps reduce appetite, increase satiety and improve glucose-dependent insulin signalling.

Retatrutide

Most weight-loss drugs are content to knock on one or two metabolic doors. Retatrutide appears to have arrived with the master key. It is an investigational triple agonist activating GLP-1, GIP and glucagon receptors.

Semaglutide

Semaglutide is a GLP-1 receptor agonist. It mimics one of the body’s meal-related signals and changes both appetite and glucose regulation.